Creatine Orotate
Combines creatine with orotic acid, a pyrimidine precursor involved in nucleotide synthesis, marketed for endurance and cardiac support.
Orotic acid may support RNA and phospholipid synthesis. Pairing it with creatine aims to address both energy and cellular repair needs, though human evidence is minimal.
Quick facts
- Usage
- Endurance or cardiac-focused stacks
- Evidence level
- Mostly theoretical and animal data
- Taste
- Neutral
Who it helps most
- Biohackers exploring nucleotide support
- Athletes under cardiologist supervision
- Users who prefer capsule delivery
Limitations & cautions
- Limited human trials
- Higher price
- Potential to elevate serum orotic acid if dosed excessively
Research highlights
Cardiometabolic rationale
Wellbeing Nutrition and Healthline reference orotate’s role in cardiac energetics, but they also stress the lack of direct performance data compared with monohydrate.
Sources: Wellbeing Nutrition – Types of Creatine, Healthline – 6 Types of Creatine
Theoretical benefits
In theory, orotate could support myocardial energy turnover alongside creatine, making it an interesting adjunct in clinical research. Athletes should view it as experimental until more trials accumulate.
Risk management
High-dose orotic acid has been linked to liver stress in animals, so stick with conservative doses and consult healthcare providers if you have hepatic or renal concerns.
Practical advice
If your primary goal is strength or hypertrophy, monohydrate remains sufficient. Use orotate only with professional guidance and lab monitoring.
Practical dosing
Typically 3 g compound (≈1.5 g creatine) daily; do not exceed label recommendations.
Sourcing checklist
Require documentation of orotic acid purity and heavy-metal testing.
Related creatine types
Compare with other creatine formats to find the best fit for your needs.
Sources
Wellbeing Nutrition – Types of Creatine
Discusses orotate theory and cautions.
Visit sourceHealthline – 6 Types of Creatine
Mentions limited evidence for orotate.
Visit source